Research Review

Tamara D. Rozental, M.D.

Assistant Professor

Dept. of Orthopaedic Surgery, Beth Israel Deaconess Medical Center

Current Clinical Research Projects at BIDMC

 

Examining the origins of skeletal fragility in premenopausal women with distal radius fractures

Purpose: To improve the understanding of the initial stages of skeletal fragility and possibly enable early identification of individuals at high risk for future broken bones. We will compare bone mineral density, morphology, microarchitecture and metabolism in premenopausal women with distal radius fractures to other premenopausal women with no history of fractures. – Submitted to JBJS

 

Fracture healing in the distal radius: Do bisphosphonates make a difference?

Purpose: To determine the time to union in distal radius fracture patients on and off bisphosphonate therapy -a type of medication for osteoporosis. Patients return at regular intervals for ROM measurements, questionnaires, and x-rays. – Enrolling Patients

 

A prospective pilot study to evaluate 25-hydroxy-vitamin D and bone turnover marker levels in patients with distal radius fractures

Purpose: To determine any relationship between Vitamin D levels and bone turnover markers in patients who present with distal radius fractures, when compared to age- and sex-matched controls. This initial, women-only pilot study will allow us to establish trends that will be used to inform a second, larger cohort study which will enroll both genders. – Enrolling Patients

 

A prospective, randomized, single-blind, multi-center clinical trial to evaluate three surgical techniques in elderly (>60yo) with distal radius fractures

Purpose: To compare how patients heal after three types of surgery used to treat distal radius fractures. The three types that will be compared are: external fixation with or without percutaneous pinning, percutaneous pinning alone, or internal fixation with the Volar Locking Plating System. These 3 methods will be compared to non-operative distal radius fracture patients. – Pending IRB approval

 

Educational Material for Patients and the Lay Community

 
Orthopaedics Today (2011): “Deterioration of trabecular bone found in premenopausal women with fractures.”
AAOS Now (2011): “Early skeletal fragility not easy to spot.”
 

Non-peer Reviewed Scientific or Medical Publications in Print or other Media

 
Rozental TD. Yearbook of hand and upper extremity surgery, Steinmann S and Yao J, editors. Elsevier, Philadelphia, 2011.
Rozental TD, LaPorte D. Reconstruction of the Hand and Wrist. In Orthopaedic Knowledge Update 10, Flynn J, editor. American Academy of Orthopaedic Surgery, Rosemont, 2011.
Toussaint RJ, Rozental TD. Distal Radius Fractures: Anatomy, Biomechanics and Classification. In Hand Surgery Update V, Chung K, editor. American Society for Surgery of the Hand, Rosemont, 2011.
Bhatt R, Rozental TD. Bone grafts and bone substitutes. Hand Clin. 2012.
Rozental TD. Yearbook of hand and upper extremity surgery, Steinmann S and Yao J, editors. Elsevier, Philadelphia, 2012.
 

Clinical Guidelines and Reports

 
Byrd G, Rozental TD. Wrist Fractures. BMJ Point-of-Care 2011 (http://online.epocrates.com) and Best Practice (http://bestpractice.bmj.com/). Last accessed January 2011
Byrd G, Rozental TD. Wrist Fractures. BMJ Point-of-Care 2012 (http://online.epocrates.com) and Best Practice (http://bestpractice.bmj.com/).
 

Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings

 
Rozental TD, Bouxsein ML, Day CS, Earp BE, Deschamps LN, Taylor AP. Premenopausal women with distal radius fractures have deteriorated bone density and morphology compared to non-fracture controls. American Society for Surgery of the Hand 66th Annual Meeting, Las Vegas, NV 2011.
Earp, BE, Han BA, Rozental TD, Dyer GS, Blazar PE. The effectiveness of corticosteroid injection for carpal tunnel syndrome: a prospective trial. American Society for Surgery of the Hand 66th Annual Meeting, Las Vegas, NV 2011.
Earp, BE, Han BA, Rozental TD, Blazar PE. The effectiveness of corticosteroid injection for de Quervain’s tenosynovitis: a prospective trial. American Society for Surgery of the Hand 66th Annual Meeting, Las Vegas, NV 2011.
Rozental TD, Bouxsein ML, Day CS, Earp BE, Deschamps LN, Taylor AP. Premenopausal women with distal radius fractures have deteriorated bone density and morphology compared to non-fracture controls. Orthopaedic Research Society, San Francisco, CA 2012.
Day CS, Rozental TD. Predictors of Secondary Displacement in Operatively and Non-Operatively Managed Distal Radius Fractures. American Academy of Orthopaedic Surgeons 77th Annual Meeting, San Francisco, CA, 2012
Rozental TD. Osteopenia, Osteoporosis and Fractures of the Distal Radius. American Society for Surgery of the Hand 67th Annual Meeting, Chicago, IL 2012.
2012 Harvard Orthopaedic Journal
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